Journal of Neural Engineering
A 10-year journey towards clinical translation of an implantable endovascular BCI (keynote lecture, BCI Society Meeting, Brussels) (opens in new tab) →
Thomas J Oxley
Research
We publish our research: peer-reviewed and publicly available. Open science drives the field forward together. Our work is hypothesis-driven in three core domains:
Sensing. What brain states and representations of cognition, including motor, can be sensed in the brain?
Models. How do we use that data to build models that represent the layers of human cognition?
Interactions. How do we build interactions from those models that help people regain meaningful agency in their lives?
CAUTION—Investigational device. Limited by Federal (or United States) law to investigational use.
Publications
2025
Journal of Neural Engineering
The 'Brussels 4': essential requirements for implantable brain-computer interface user autonomy (opens in new tab) →
Oxley, T. J., Deo, D. R., Cernera, S., Sawyer, A., Putrino, D., Ramsey, N. F., & Fry, A.
Journal of Neural Engineering
Motor activity in gamma and high gamma bands recorded with a Stentrode from the human motor cortex in two people with ALS (opens in new tab) →
K Kacker, N Chetty, AK Feldman, J Bennett, PE Yoo, A Fry, D Lacomis, et al.
Journal of Neural Engineering
Building consensus on clinical outcome assessments for BCI devices (opens in new tab) →
A Sawyer, N Chetty, DP McMullen, H Dean, J Eisler, M Fried-Oken, et al.
Journal of NeuroInterventional Surgery
Characterizing superficial cerebral cortical venous anatomy for endovascular device implantation: a cross-sectional imaging study (opens in new tab) →
J Brannigan, A Kian, C Eiber, VSA Tarigoppula, J Bogard, AH Siddiqui, et al.
IEEE Transactions on Neural Systems and Rehabilitation Engineering
Artifact removal in electrocorticography devices with cardiac contamination (opens in new tab) →
KA Liyanage, PE Yoo, DB Grayden, NL Opie, TJ Oxley
medRxiv (preprint)
Motor cortex coverage predicts signal strength of a Stentrode endovascular brain-computer interface (opens in new tab) →
HR Schone, P Yoo, A Fry, N Chetty, A Sawyer, C Herbers, F Liu, CH Moon, et al.
medRxiv (preprint)
Signal properties and stability of a chronically implanted endovascular brain-computer interface (opens in new tab) →
N Chetty, K Kacker, AK Feldman, PE Yoo, J Bennett, A Fry, I Tal, NF Hardy, et al.
2024
Stroke
Endovascular brain-computer interfaces in poststroke paralysis (opens in new tab) →
JFM Brannigan, A Fry, NL Opie, BCV Campbell, PJ Mitchell, TJ Oxley
American Journal of Physical Medicine & Rehabilitation
The promise of endovascular neurotechnology: a brain-computer interface to restore autonomy to people with motor impairment (opens in new tab) →
TJ Oxley
Journal of NeuroInterventional Surgery
Superior cortical venous anatomy for endovascular device implantation: a systematic review (opens in new tab) →
J Brannigan, A McClanahan, F Hui, KM Fargen, N Pinter, TJ Oxley
2023
Journal of Neuroradiology (ScienceDirect)
Cerebral venous disorders: Diagnosis and endovascular management (opens in new tab) →
Abdalkader, M., Hui, F., Amans, M. R., et al.
Policy, Identity, and Neurotechnology (Springer)
Ethical Considerations of Endovascular Brain–Computer Interfaces (opens in new tab) →
Fry, A., Breyman, E., LaGrassa, E., Oxley, T., & Putrino, D.
JAMA Neurology
Assessment of Safety of a Fully Implanted Endovascular Brain-Computer Interface for Severe Paralysis in 4 Patients (opens in new tab) →
Mitchell, P., Lee, S. C. M., Yoo, P. E., et al.
2022
Archives of Physical Medicine and Rehabilitation
Long-Term Safety of a Fully Implanted Endovascular Brain-Computer Interface for Severe Paralysis (opens in new tab) →
Thomas Oxley
Journal of Neural Engineering (IOP Science)
Vascular remodeling in sheep implanted with endovascular neural interface (opens in new tab) →
John, S. E., et al.
2021
IEEE Engineering in Medicine & Biology Society (EMBC)
Feasibility of using discrete Brain Computer Interface for people with Multiple Sclerosis (opens in new tab) →
Shiels, T. A., et al.
2020
IEEE
Safe Retrieval of a Stent-Based Endovascular Neural Recording Array (opens in new tab) →
Tarigoppula, V. S. A., Rind, G. S., Ronayne, S. M., et al.
IEEE International Winter Conference on Brain-Computer Interface
Mechanical suitability of an endovascular brain-computer interface (opens in new tab) →
Opie, N. L., Ronayne, S. M., Rind, G. S., Yoo, P. E., & Oxley, T. J.
Journal of NeuroInterventional Surgery (JNIS)
Motor neuroprosthesis implanted with neurointerventional surgery improves capacity for activities of daily living tasks in severe paralysis: first in-human experience (opens in new tab) →
Oxley, T. J., et al.
2019
Neurosurgery (Europe PMC)
Sensor modalities for brain-computer interface technology (opens in new tab) →
Martini, M. L., Oermann, E. K., Opie, N. L., et al.
Bioelectronics in Medicine (Future Medicine)
Removing the need for invasive brain surgery: the potential of stent electrodes (opens in new tab) →
Opie, N. L., & Oxley, T. J.
2018
IEEE/EMBS Conference on Neural Engineering (NER)
Cortical Brain Stimulation with Endovascular Electrodes (opens in new tab) →
Gerboni, G., John, S. E., Ronayne, S. M., et al.
IEEE Transactions on Biomedical Engineering
In vivo impedance characterization of cortical recording electrodes shows dependence on electrode location and size (opens in new tab) →
John, S. E., Apollo, N. V., Opie, N. L., et al.
IEEE Engineering in Medicine and Biology Society (EMBC)
Effect of Implant Duration, Anatomical Location and Electrode Orientation on Bandwidth Recorded with a Chronically Implanted Endovascular Stent-Electrode Array (opens in new tab) →
Opie, N. L., John, S. E., Rind, G. S., et al.
IEEE Sensors Letters
A Stent-Based Power and Data Link for Sensing Intravascular Biological Indicators (opens in new tab) →
Aldaoud, A. J., Redout, J. M., Ganesan, K., et al.
Biomedical Physics & Engineering Express
Visual evoked potentials determine chronic signal quality in a stent-electrode endovascular neural interface (opens in new tab) →
Gerboni, G., John, S. E., Rind, G. S., et al.
Magnetic Resonance Materials in Physics
Optimized partial-coverage functional analysis pipeline (OPFAF): a semi-automated pipeline for skull-stripping and co-registration of partial-coverage, ultra-high-field functional images (opens in new tab) →
Yoo, P. E., Cleary, J. O., Kolbe, S. C., et al.
IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology
Near-Field Wireless Power Transfer to Stent-Based Biomedical Implant (opens in new tab) →
Aldaoud, A. J., Ganesan, R. K., Rind, G. S., et al.
Scientific Reports
Feasibility of identifying the ideal locations for motor intention decoding using unimodal and multimodal classification at 7T-fMRI (opens in new tab) →
Yoo, P. E., Oxley, T. J., John, S. E., et al.
World Neurosurgery (ScienceDirect)
Closed loop neurostimulation: Listen to the body (opens in new tab) →
Oxley, T. J., & Opie, N. L.
Nature Biomedical Engineering
Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent (opens in new tab) →
Opie, N. L., John, S. E., Rind, G. S., et al.
Scientific Reports
Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable (opens in new tab) →
John, S. E., Opie, N. L., Wong, Y. T., et al.
Human Brain Mapping
Spatially dynamic recurrent information flow across long-range dorsal motor network encodes selective motor goals (opens in new tab) →
Yoo, P. E., Hagan, M. A., John, S. E., et al.
NeuroImage (ScienceDirect)
7T-fMRI: Faster temporal resolution yields optimal BOLD sensitivity for functional network imaging specifically at high spatial resolution (opens in new tab) →
Yoo, P. E., John, S. E., Farquharson, S., et al.
2017
Neuroscience & Biobehavioral Reviews
The Ovine Motor Cortex: A Review of Functional Mapping and Cytoarchitecture (opens in new tab) →
John, S. E., Lovell, T. J. H., Opie, N. L., et al.
Frontiers in Neurology
Advanced imaging of intracranial atherosclerosis: lessons from interventional cardiology (opens in new tab) →
Pavlin-Premrl, D., Sharma, R., Campbell, B. C., et al.
Neurosurgical Focus
The evolution of endovascular electroencephalography: historical perspective and future applications (opens in new tab) →
Sefcik, R. K., Opie, N. L., John, S. E., et al.
2016
PLoS One
Development and Implementation of a Corriedale Ovine Brain Atlas for Use in Atlas-Based Segmentation (opens in new tab) →
Liyanage, K. A., Steward, C., Moffat, B. A., et al.
Nature Biotechnology
Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity (opens in new tab) →
Oxley, T. J., Opie, N. L., John, S. E., et al.
IEEE Transactions on Biomedical Engineering
Micro-CT and Histological Evaluation of a Neural Interface Implanted within a Blood Vessel (opens in new tab) →
Opie, N. L., van der Nagel, N. R., John, S. E., et al.
Journal of Neural Engineering
Chronic impedance spectroscopy of an endovascular stent-electrode array (opens in new tab) →
Opie, N. L., John, S. E., Rind, G. S., et al.
IEEE Engineering in Medicine and Biology Society (EMBC)
Suitability of nitinol electrodes in neural prostheses such as endovascular neural interfaces (opens in new tab) →
Wong, Y. T., Opie, N. L., John, S. E., et al.
Journal of Neurosurgery
An ovine model of cerebral catheter venography for implantation of an endovascular neural interface (opens in new tab) →
Oxley, T. J., Opie, N. L., Rind, G. S., et al.
IEEE Engineering in Medicine and Biology Society (EMBC)
Feasibility of a chronic, minimally invasive endovascular neural interface (opens in new tab) →
Opie, N. L., Rind, G. S., John, S. E., et al.